ef1da23cbc This is the 25th recurrence at this site in 10 years. Decision making can be guided with vaginal herpes cultures at regular intervals during the third trimester. Viral shedding is decreased by 1 days and roughly leads to complete lesion healing 1 day faster than placebo. Sign in for access to Learning Sign in to your personal account Create a free personal account A free personal account provides Access to CME. All these regimens were superior to the 250 mg once a day dosage (22% recurrence free) and placebo (5%).80,81 More complete suppression was attained in patients with baseline disease activity of less than 10 recurrences per year, with the 500 mg once a day dosage typically sufficient for control.
Acquisition of data: Cernik. Some suggestions: Go back to the last page Go to the home page .. Back to top Article Information Correspondence: Robert T. Search . Neither regimen appears to affect the frequency or course of future genital herpes recurrences.39 Head-to-head trials comparing 10-day regimens of oral acyclovir (200 mg 5 times daily) and valacyclovir (1000 mg twice a day) found no statistically significant difference between the 2 in terms of disease outcome measures.40 However, valacyclovir, when taken once or twice daily, is likely to increase compliance compared with acyclovir, which is taken 5 times a day.40 Similarly, an RCT comparing the efficacy of 5- and 10-day regimens of several famciclovir dosages (250 mg, 500 mg, or 750 mg 3 times a day for 5 days and 125 mg, 250 mg, or 500 mg 3 times a day for 10 days) with acyclovir (200 mg 5 times a day for 5 or 10 days) in first-episode genital herpes cases found no significant differences between the two drugs. Drafting of the manuscript: Cernik and Brodell. Arch Intern Med. There is a 50% absolute risk reduction of developing new lesions compared with placebo, and the treatment group enjoyed at least a half-day reduction in lesion-associated pain and discomfort.51,52 A single-day, 2-dose regimen demonstrated a 2-day reduction in median time to healing and overall efficacy equal to that of multiple day, lower-dose famciclovir regimens.14Table 4 summarizes these data.
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